Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile in nor

• 作 者: Si-Yuan PAN Qing YU Yi ZHANG Xiao-Yan WANG Nan SUN Zhi-Ling YU Kam-Ming KO
• 机 构: Department of Pharmacology,Beijing University of Chinese Medicine,Beijing 100102,China
• 出 处: 第二届世界天然药物和传统药物药理学学术会议
• 发表日期: 2012年8期
• 关键词: Fructus Schisandrae Chinensis fenofibrate fatty liver hypercholesterolemia hepat

　　AIM To investigate the effects of dietary intake of Fructus Schisandrae chinensis (FSC), both aqueous and ethanolic extracts (AqFSC, EtFSC), on serum/hepatic lipid contents in normal diet (ND)-and high-fat/cholesterol/bile salt diet (HFCBD)-fed mice.METHODS Male ICR mice were fed with ND or HFCBD, supplemented with 1 and 4% of AqFSC and EtFSC, respectively, or 0.1% fenofibrate, for 13 d.Lipids were determined according to the manufactures instructions.RESULTS EtFSC, but not AqFSC, significantly elevated hepatic triglyceride (TG) in mice fed with ND.Feeding mice with HFCBD increased serum total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) levels as well as alanine aminotransferase (ALT)activity.Supplementation with AqFSC, EtFSC or fenofibrate significantly reduced hepatic TC and TG levels.However, AqFSC and EtFSC supplementation increased serum HDL and LDL levels in mice fed with HFCBD.Fenofibrate increased serum HDL and reduced serum LDL contents in hypercholesterolemic mice.EtFSC reduced, but fenofibrate elevated, serum ALT activity in both normal and hypereholesterolemic mice.While fenofibrate reduced serum TC, TG, and HDL levels in mice fed with ND, it increased serum HDL and reduced serum LDL, TC, and TG levels in mice fed with HFCBD.Hepatomegaly was found in normal and hypercholesterolemic mice fed with diet supplemented with fenofibrate.LD50 value of AqFSC and EtFSC was estimated to be (43.24 ±7.79)g·kg-1 and 40.35 +6.22, respectively, using the Bliss method.CONCLUSION Feeding mice with AqFSC and EtFSC ameliorated the HFCBDinduced hepatic steatosis.In addition, EtFSC may offer protection against hepatic injury in hypercholesterolemic mice.