【摘 要】
：
Ku80 is one of the most important factors determining.The aim of our study was to detect the expression of Ku80 on primary central nervous system lymphoma and to e valuate the relationship between Ku8
【机 构】
：
浙江大学医学院附属邵逸夫医院神经外科
论文部分内容阅读
Ku80 is one of the most important factors determining.The aim of our study was to detect the expression of Ku80 on primary central nervous system lymphoma and to e valuate the relationship between Ku80 expression level and clinical outcomes.38 pa tients with PCNSL were included in this retrospective study.The expression of Ku80 in tumor samples was determined by immunohistochemistry.One thousand neoplastic cells per specimen were counted.The expression levels were compared with the clini cal data and statistical analyzed.The results of this study show the expression of Ku80 can be found in the majority of PCNSLs.The mean expression level of Ku80 in 38 PCNSL is 64.1±24.5.A significant difference in Ku80 expression could be found between age<65 years group and age≥65 years group (P=0.006).Kaplan-Meier analysis revealed that patients who showed a high Ku80 expression had a significantly shorter median survival time (MST) than patients who had low Ku80 expression (P =0.036).Patients age, tumor location, treatment protocol were significantly related with prognosis in PCNSL (P<0.05).The expression of Ku80 was observed in the majority of PCNSLs.Ku80 was a predictive factor for survival in this study.In addition to Ku80, other clinical variables including age, tumor location and therapeutic protocol are correlated significantly with overall survival.
其他文献
目的：了解辣椒素的经肠转运特性，并通过研究辣椒素转运特性与肠粘膜上一些转运体或通道之间的关系，来阐明产生这种转运特性的机制;方法和结果：建立辣椒素的高效液相检测方法，用于测定体外经肠粘膜透过的样品中辣椒素的含量。应用荧光分光光度法，建立罗丹明123(R123)及荧光素钠(CF)检测方法学。应用高效液相质谱联用仪器建立血浆中辣椒素的定量方法。使用体外Ussing chamber实验评价辣椒素经不同肠
目的：探讨临床表现及生化检查高度怀疑垂体ACTH腺瘤,但MRI影像检查不能清楚定位的患者,采用岩下窦采血技术,来明确诊断并定位肿瘤的位置.方法：近1年来共有2例高度怀疑垂体ACTH腺瘤患者MRI检查不能明确显示病灶,行岩下窦采血.术中操作要点:1.双侧股静脉置鞘,一侧为6F鞘,一侧为5F鞘,以便双侧岩下窦同时采血,同时6F鞘侧可以方便的采取外周静脉血以便对照;2.采用4F单弯导管在导丝辅助下进入岩
目的 通过检测人类脑膜瘤中凋亡相关基因BAG-1的表达,以进一步了解脑膜瘤的生物学行为. 方法 对158例脑膜瘤病理标本采用免疫组化SP法,直接检测BAG-1的表达情况.按染色强度和阳性范围评估免疫组化检测结果 ,分析BAG-1表达程度与脑膜瘤瘤周水肿、术后复发的关系. 结果 随着脑膜瘤BAG-1表达的免疫组化评分下降,脑膜瘤瘤周水肿程度加重、术后更易复发,其结果 均具有统计学意义(x2=43
Background: Ganglioglioma is a generally benign tumor, mostly occurring in patients younger than 30 years old.Temporal lobe is the most frequently involved location, but no other regions are spared.Up
目的：研究胶质纤维酸性蛋白(GFAP)、S100和Ki-67在人脑胶质瘤肿瘤细胞中的表达,探讨其表达程度同胶质瘤分级之间的关系及其临床意义.方法：收集统计宁波市医疗中心李惠利医院2010年1月至2013年6月住院并行手术治疗的31例胶质瘤患者肿瘤切除标本的病理检查结果 及GFAP,S100及Ki-67的免疫组织化学检查结果.结果：GFAP,S100和Ki-67三者在各级别的胶质瘤中均有不同程度的表
Objective: Nogo-A is a member of the reticulon family, enriched in the central ner vous system (CNS), its extracellular domain Nogo-66 has a growth inhibitory activity that is specific for neurons, me
Primary melanocytic tumors of the central nervous system (CNS) are rare lesions, but primary sellar tumors are rarer.Only 10 cases have been reported, and they are often misdiagnosed as pituitary macr
Background Malignant myoepithelioma is a relatively rare malignant tumor occurring most frequent ly in the salivary glands.A few isolated cases have been described in other locations,including soft ti