A direct nickel-catalyzed,high atom-and step-economical reaction of cyanohydrins with aldehydes or ketones via an unprecedented “cyano-borrowing reaction” has been developed.
α,β-Unsaturated compounds are of intensive interest as they are highly valuable intermediates for the synthesis of numerous fine chemicals and pharmaceuticals.1-2 On the other side,organofluorine comp
Recently,substitution of the C=C functionality with the isosteric and isoelectronic B-N moiety has emerged as a powerful way to expand the family of polycyclic aromatic hydrocarbons(PAHs).
Transition metal-catalyzed cycloaddition reactions have been determined to be a powerful tool for constructing valuable heterocyclic skeletons.In particular,a variety of dipolar cycloadditions of in s
Indolines and oxindoles bearing C-3 chiral quaternary carbon centers are ubiquitous subunits in a lot of alkaloids and biologically active compounds,and thus it is not surprising to see explosive inte
As an alternative to the conjugate addition of organometallic reagents to α,?-unsaturated carbonyl compounds,the direct addition of C?H bonds to unsaturated carbon-carbon bonds has been intensively in
Carbon-carbon single bonds are undoubtedly considered as one of the least reactive “functional” groups among a wide range of organic functionalities that can be activated by transition metal complexes