【摘 要】
：
目的 初步探索通过HIFU实现体外三维可视化定向血管消融栓塞的可行性.方法 选取小型猪肝脏的为研究对象，采用前期完成的MRI三维重建与实时B超图像融合及配准方法，选取融合图像上可见而实时超声图像上不能识别的小动脉进行HIFU定向消融；通过声诺维明确靶区血供缺失后停止治疗.术后手术切取靶区组织，肉眼及显微镜下观察靶区.结果 在三维可视化系统帮助下，通过HIFU成功消融小型猪肝脏三支直径约2mm的小动
【机 构】
：
重庆医科大学附属第二医院 重庆医科大学附属第一医院放射科
【出 处】
：
中国超声医学工程学会成立30周年暨第十二届全国超声医学学术大会
论文部分内容阅读
目的 初步探索通过HIFU实现体外三维可视化定向血管消融栓塞的可行性.方法 选取小型猪肝脏的为研究对象，采用前期完成的MRI三维重建与实时B超图像融合及配准方法，选取融合图像上可见而实时超声图像上不能识别的小动脉进行HIFU定向消融；通过声诺维明确靶区血供缺失后停止治疗.术后手术切取靶区组织，肉眼及显微镜下观察靶区.结果 在三维可视化系统帮助下，通过HIFU成功消融小型猪肝脏三支直径约2mm的小动脉；肉眼见靶灰白色凝固性坏死，其周围见暗红色充血区，再外围为苍白色反应带，最大截面分别为22.6mm2； 26.4mm2；19.8 mm2；显微镜下见靶区肝内微血管内皮严重破坏，血管壁塌陷，肝板破坏，肝细胞核固缩.结论 精确图像融合的三维可视化与HIFU技术结合，可实现体外无创的定向血管消融，达到栓塞目标血管的作用，在实体肿瘤治疗中有巨大潜在辅助治疗价值.
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