Copper-Catalyzed C-Alkylation of Secondary Alcohols and Methyl Ketones with Alcohols Employing the A

• 作 者: ShihengLiao;QingXu;
• 机 构: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035
• 出 处: 中国化学会第28届学术年会
• 发表日期: 2012年期

　　Alcohols are a class of green chemicals in many aspects.1 In addition to the N-alkylation reactions,they have also been used as the alkylating reagents in C-alkylation reactions by employing the borrowing hydrogen or hydrogen autotransfer methodology.1a-g However,severe drawbacks still remain in these methods.Based on our previous aerobic N-alkyaltion studies,2 we further found that coppers are also more effective and more advantageous catalysts than other transition metals in the C-alkylation of secondary alcohols and methyl ketones under the aerobic conditions.Based on our mechanistic studies and also supported by the literature,the novel relay race mechanism that has not been noticed and discovered in previous aerobic C-alkylation reactions4 was proposed for the first time for the Cu-catalyzed aerobic reactions,and we also deduce that the previously-concluded borrowing hydrogen-type mechanisms in the aerobic C-alkylation reactions were possibly wrong.4