Intracellular mechanisms underlying α2A-adrenergic suppression of prefrontal cortical excitatory syn

• 作 者: Feng YI Fei LUO Xue-Han ZHANG Bao-Ming LI
• 机 构: Institute of Neurobiology & State Key Laboratory of Medical Neurobiology, Institutes of Brain Scienc
• 出 处: 中国神经科学学会第九届全国学术会议暨第五届会员代表大会
• 发表日期: 2011年1期
• 关键词: α2A-adrenoceptor excitatory synaptic transmission intracellular mechanism medial

　　Stimulation of α2A-adrenoceptors (ARs) in the prefrontal cortex (PFC) produces a beneficial effect on cognitive functions such as working memory.The α2A-adrenergic agonist guanfacine has been used for treatment of psychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD).A previous study in our laboratory showed that stimulation of α2A-AR suppresses excitatory synaptic transmission in pyramidal cells of the rat medial prefrontal cortex (mPFC).However, the intracellular mechanism underlying the α2A-AR suppression remains unclear.In the present study, we recorded evoked excitatory postsynaptic current (eEPSC) in layer Ⅴ-Ⅵ pyramidal cells of the mPFC, using whole-cell patch-clamp recording technique, and found that the α2A-AR inhibition of excitatory synaptic transmission is mediated via Gi-cAMP-PKA-PP 1 and/or Gi-cAMP-PKA-PP 1-CaMKII signaling pathways.