【摘 要】
：
In 2000, Perou, et al.showed in their seminal "nature" paper that the phenotypic diversity of breast carcinomas is accompanied by a corresponding diversity
【机 构】
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Medical University of Graz Austria
【出 处】
：
2011第四届世界癌症大会暨乳腺癌峰会
论文部分内容阅读
In 2000, Perou, et al.showed in their seminal "nature" paper that the phenotypic diversity of breast carcinomas is accompanied by a corresponding diversity in gene expression patterns (GEP) that can be captured using cDNA microarrays.For the first time, it was demonstrated that breast cancers could be classified into distinctive subtypes distinguished by characteristic differences in their GEP or their "molecular portraits".This study and the subsequent study in 2001 by Sorlie, et al.had a major impact on both molecular biologists and oncologists and also challenged the traditional histopathological classification system of breast carcinomas, particularly with regard to a new "entity" of basal-like carcinoma.
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