XPC维持骨髓间充质干细胞自稳防止恶性转化的作用研究

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户：asdf20091234567889

【摘要】

：

肿瘤及肿瘤干细胞的发生与成体干细胞衰老、分化异常导致的恶性转化密切相关.DNA损伤应答系统是细胞维持基因组稳定的主要防御机制，近来在P53等DNA损伤应答分子的研究中发现DNA损伤应答系统在干细胞自稳中发挥多层面作用.XPC作为重要的DNA修复与细胞周期调控分子，其异常可导致多种肿瘤发生，但XPC在干细胞自稳中的角色尚未探及.

【作者】

：

余瑾王婷婷王韵黄亚琴陈志文杨劲

【机构】

：

中国人民解放军第三军医大学细胞生物学教研室,重庆,400038 中国人民解放军西南医院全军泌尿外科

【出处】

：

中国细胞生物学学会2015年全国学术大会

【发表日期】

：

2015年4期

【关键词】

：

间充质干细胞 XPC基因组稳定性 DNA损伤修复恶性转化端粒

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XPC维持骨髓间充质干细胞自稳防止恶性转化的作用研究

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