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It has been showed that Insulin-like growth factor-1 (IGF-1) may be related with bone mineral density (BMD) or osteoporosis.But little is known about genetic variation in IGF-1 was associated with BMD or osteoporosis.Here, we observed the association of polymorphisms in IGF-1 (rs35767) and BMD in Chinese postmenopausal female population.A total of 168 women completed a questionnaire and BMD was measured by dual energy x-ray absorptiometry (DEXA) at the lumbar spine L2-L4, femoral neck and femoral trochanter.The polymorphism was determined by direct sequence analysis of PCR of genomic DNA.All 168 subjects fall within three genotypes (CC, CT and TT) at rs35767 site.The prevalence of each genotype was 48.2% CT, 40.5% CC, and 11.3% TT.The genotype frequencies satisfied the Hardy-Weinberg equilibrium (x2 =0.59, P> 0.05).Although, there was no significant association between polymorphisms in IGF-l(rs35767) and BMD/osteoporosis, the BMD of women with TT alleles were lower than those with CC alleles by 4.5%, 7.2%, 6.6% and 6.2% for L2-L4, femoral neck, femoral trochanter and proximal femur, respectively (all the P values <0.05).Our results suggested that polymorphisms in IGF-1 (rs35767) may be a susceptible loci for reduced BMD in Chinese postmenopausal women.