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  5. pH-Sensitive Drug Release in Enhancing Cytotoxicity Mediated by Chitosan based Glycolipid-like Nanoc

pH-Sensitive Drug Release in Enhancing Cytotoxicity Mediated by Chitosan based Glycolipid-like Nanoc

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：liongliong484
【摘 要】
：
In our previous study, we can delivery drug to specific issues and cells.However, the problems of drug release in tumor cells and intracellular drug process cannot be solved So we have developed a chi
【作 者】
：
Bolin Cheng BinBin Lu Xuan Liu Yun Zhu Hong Yuan Fuqiang Hu 
【机 构】
：
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
【发表日期】
：
2015年9期
【关键词】
：
pH-sensitive chitosan based glycolipid-like nanocarrier Schiff-base triggered dr 
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　　In our previous study, we can delivery drug to specific issues and cells.However, the problems of drug release in tumor cells and intracellular drug process cannot be solved So we have developed a chitosan based glycolipid-like nanocarrier(CSO-FBA-SA) which responded to the low pH environment in lysosome.4-formylbenzoic acid was chosen as linker and the Schiff-base bond [1] was formatted between chitosan and octadecanol.
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