Clonal population structure of Cryptosporidium parvum Ⅱd family:common ancestry origin and likely di

• 作 者: RongjunWang[1]ChaochaoLv[1]ZifangZhao[1]MengQi[1]HaijvDong[1]HeleiWang[1]YanruSun[1]ChangshenNing[1]LihuaXiao[1]LongxianZhang[2]CharlotteAxén[3]CamillaBjorkman[1]FuchunJian[4]SaidAmer[5]AiqinLiu[6]Yao
• 机 构: College of Animal Science and Veterinary Medicine,Henan Agricultural University,Zhengzhou,China
• 出 处: 中国畜牧兽医学会家畜寄生虫学分会第七次代表大会暨第十二次学术研讨会
• 发表日期: 2013年期

　　In the present study,111 Cryptosporidium parvum Ⅱd isolates from several species of animals in China,Sweden,and Egypt were subtyped by multilocus sequence typing (MLST).One to eleven subtypes were detected at each of the 12 microsatellite,minisatellite,and single nucleotide polymorphism (SNP) loci,forming 25 MLST subtypes.Host:adaptation and significant geographical segregation were both observed in the MLST subtypes.A clonal population structure was seen in C.parvum Ⅱd isolates from China and Sweden Three ancestral lineages and the same RPGR sequence were shared by these isolates examined.Therefore,the.present genetic observations including the higher nucleotide diversity ofC.parvum Ⅱid GP60 sequences in Western Asia,as well as the unique distribution ofⅡd subtypes (almost exclusively found in Asia,Europe,and Egypt) and in combination with the domestication history of cattle,sheep,and goats,indicated that C.parvum Ⅱd subtypes derived from a common ancestry and probably dispersed from Western Asia to other geographical regions.More population genetic structure studies involving various C.parvum subtype families using high:resolution tools are needed to better elucidate the origin and dissemination ofC.parvum in the world.