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  5. Hypercholesterolemia Up-Regulates the Expression of Intermedin and Its Receptor Components in the Ao

Hypercholesterolemia Up-Regulates the Expression of Intermedin and Its Receptor Components in the Ao

来源 :The Pulse of Asia 2015(第七届亚洲动脉年会) | 被引量 : 0次 | 上传用户：chen95127
【摘 要】
：
Objective: Hypercholesterolemia can cause damage to the artery before the atherosclerotic lesion has formed.Intermedin (IMD) is a novel member of the calcitonin gene-related peptide family.Endogenous
【作 者】
：
Xiaoping Chen Qingtao Meng Di Shi Jiayue Feng Sen He Si Wang Yong Wang Kai Liu 
【机 构】
：
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China
【出 处】
：
The Pulse of Asia 2015(第七届亚洲动脉年会)
【发表日期】
：
2015年9期
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Objective: Hypercholesterolemia can cause damage to the artery before the atherosclerotic lesion has formed.Intermedin (IMD) is a novel member of the calcitonin gene-related peptide family.Endogenous IMD is reported to participate in several cardiovascular pathological states.Using the rats fed with high-cholesterol diet, this study aims to investigate the aortic expression of IMD and its receptors in hypercholesterolemia without atherosclerosis.Furthermore, by the antioxidant intervention, we also explore the influence of oxidative stress.
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