【摘 要】
：
A tandem reaction of ring opening of a polyepoxide is well documented in which promoter such as acid, base, radical were employed.However, very few transition metal catalyzed promotion has been report
【机 构】
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Department of Pharmaceutical Chemistry,Kyoto Pharmaceutical University Misasagi,Yamashina,Kyoto 607-
【出 处】
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The 24th International Society of Heterocyclic Chemistry Con
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A tandem reaction of ring opening of a polyepoxide is well documented in which promoter such as acid, base, radical were employed.However, very few transition metal catalyzed promotion has been reported.Herein, we describe that the pdⅡ-promoted epoxide ring opening reaction of chiral allylic alcohols 1a and 1b bearing an internal epoxide and a terminal hydroxy group proceeded in a 5-exo-tet mode to afford bis-THF compounds 2a and 2b, respectively.The chiral center of the allylic alcohol is transferred with retention of the configuration on the newly formed THF ring with a syn-SN2 type fashion.
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