【摘 要】
：
目的 观察5-HT2C受体激动剂Ro60-0175对大鼠环境和线索诱导的海洛因复吸的影响.方法 成年雄性SpragueDawley大鼠建立海洛因自身给药模型,固定比率程序FR1,每天4h,持续10
【机 构】
：
宁波大学行为神经科学研究中心宁波市微循环与莨菪类药研究所宁波戒毒研究中心,江苏宁波315010
【出 处】
：
第十四届中国神经精神药理学学术会议
论文部分内容阅读
目的 观察5-HT2C受体激动剂Ro60-0175对大鼠环境和线索诱导的海洛因复吸的影响.方法 成年雄性SpragueDawley大鼠建立海洛因自身给药模型,固定比率程序FR1,每天4h,持续10 d；训练完成后构建消退模型,每天消退2h,持续14 d；训练结束后随机分成3组,在测试前15 min ip给予5-HT2C受体激动剂Ro60-0175(0.3和1 mg·kg-1)；将SD大鼠放置回训练笼,测环境和线索诱导的行为反应.
其他文献
OBJECTIVE To investigate effect of AQP4 knock out on the function of glutamate system in morphine-dependent mice.METHODS AQP4 knockout mice was chronically
OBJECTIVE To investigate the Selectivity and function of Y-QA14, a novel human Dopamine D3 receptor lig and.METHODS Receptor-binding assays was used for the
OBJECTIVE To investigate the neuropsychological underpinnings of this impaired impulsive control network.METHODS Twenty two abstinent heroin dependent (HD)
目的 分析ATPase6,8在纳米氧化锌(ZnO NP)诱导正常人肝细胞(HL-7702)线粒体氧化磷酸化能量代谢障碍中的作用,为ZnO NP疾病防控提供基础数据.方法 透射电镜和马尔文粒径分析仪
目的 评价淄博市蔬菜中砷(As)、镉(Cd)、铅(Pb)和汞(Hg)的污染状况,评估经膳食途径摄入重金属的人体健康风险.方法 对2015-2019年采集的612份叶菜类、根菜类、果菜类和茎菜类
OBJECTIVE To investigate the training, extinc tion with cue isolation and reinstatement models of heroin see king.METHODS Training: Male Sprague-Dawley rats
OBJECTIVE To explore whether the interaction occures between MOR and imidazoline receptor antisera-selected (IRAS) and that is responsible for I1 R regulati
OBJECTIVE To investigate the effect of d-Cycloserine (DCS) on morphine-induced conditioned place preference (CPP) and heroin-induced self-administration (SA
OBJECTIVE Utilized resting-state functional con nectivity MRI (fcMRI) to investigate relationship of the altera tion in the amygdala functional connectivity
OBJECTIVE To examine whether PEBP partici pates in opioid dependence through modulating activation of MAPK pathway.METHODS AND RESULTS In CHO cell stably ex