【摘 要】
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Attention plays a critical role in establishing long-last memory,yet the neural mechanisms have not been clearly elucidated.Based on recent observations that cortical information representation during
【机 构】
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北京师范大学脑与认知科学研究院,IDG-麦戈文脑研究所
论文部分内容阅读
Attention plays a critical role in establishing long-last memory,yet the neural mechanisms have not been clearly elucidated.Based on recent observations that cortical information representation during encoding is essential to memory encoding,we developed and tested the hypothesis that attention control processes implemented in the prefrontal cortex,contribute to memory by enhancing the fidelity of cortical representation of studied materials.In a series of studies,we obtained several lines of evidence to support this hypothesis.First,we found during memory encoding,frontal activities correlated with the fidelity of neural pattern measured as item-and category-level pattern similarity in the sensory cortex,which was associated with memory performance.Second,across subjects,the positive correlation between frontal activities and memory performance was mediated by the pattern similarity in the sensory cortex.Third,prefrontal cortex activation could compensate the reduced fidelity of cortical representation in old adults.Finally,anodal stimulation over the prefrontal cortex enhanced the fidelity of cortical representation and memory performance.
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