论文部分内容阅读
Microarray-based comparative genomic hybridization (array CGH) has emerged as the method of choice for detecting submicroscopic chromosomal imbalances in patients with disorders such as mental retardation (MR) or developmental delay (DD).Array CGH enables genome-wide screening at a resolution not achievable using conventional cytogenetic methods such as fluorescence in situ hybridization (FISH) or BAC array CGH.With array CGH, researchers or clinician can now have the ability to directly correlate chromosomal abnormalities to genomic sequence.