Down-regulation of Histone Deacetylase 1 by microRNA-520h contributes to the chemotherapeutic effect

来源 :2015苏浙皖赣肿瘤内科治疗进展高峰论坛暨江苏省第七次肿瘤化疗与生物治疗学术会议 | 被引量 : 0次 | 上传用户：andalee

【摘要】

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【作者】

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Qi Shen Qinghua Yao Jie Sun Lifeng Feng Haiqi Lu Yanning Ma Leining Liu Faliang Wang Jiaqiu Li Yongfang Yue Hongchuan Jin Xian Wang

【机构】

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Department of Medical Oncology, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University,31

【出处】

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2015苏浙皖赣肿瘤内科治疗进展高峰论坛暨江苏省第七次肿瘤化疗与生物治疗学术会议

【发表日期】

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2015年1期

【关键词】

：

doxorubicin HDAC1 microRNA drug resistance

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　　AIM: To study the mechanism and effect of down-regulation of Histone Deacetylase 1 (HDAC1) by microRNA-520h in the chemotherapeutic effect of doxorubicin.METHOD: Down-regulation of HDAC1 by doxorubicin treatment was detected by western blot analysis.Quantitative RT-PCR and western blot were performed to find out the combination of HDAC 1and miR-520h.

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Down-regulation of Histone Deacetylase 1 by microRNA-520h contributes to the chemotherapeutic effect

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