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The present study was designed to investigate the hepatoprotective effect of soybean protein isolate(SPI)against carbon tetrachloride-induced damage in KunMing male mice.SPI and 11S,7S proteins at a dose of 300、500、700 mg/kg was orally administered to mice,we also add a group of mice which was given SPI fodder(20%SPI was contained),for 15 days.