Tumor Necrosis Factor-α/CD40 Ligand-engineered Mesenchymal Stem Cells: Toward the Development of a N

来源 :2014第七届世界癌症大会 | 被引量 : 0次 | 上传用户：XIAOYU2529

【摘要】

：

【作者】

：

Farid Menaa

【机构】

：

Fluorotronics, Inc.USA

【出处】

：

2014第七届世界癌症大会

【发表日期】

：

2014年12期

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　　The interaction between mesenchymal stem cells (MSCs) and dendritic cells (DCs) affects T cell development and function.Further, the chemotactic capacity of MSCs, their interaction with the tumor microenvironment, and the intervention of immune-stimulatory molecules suggest possible exploitation of tumor necrosis factor-α (TNF-α) and CD40 ligand (CD40L) to genetically modify MSCs for enhanced cancer therapy.Both DCs and MSCs were isolated from BALB/c mice.

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Tumor Necrosis Factor-α/CD40 Ligand-engineered Mesenchymal Stem Cells: Toward the Development of a N

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