促红细胞生成素在急性肺损伤/急性呼吸窘迫综合征中作用的研究进展

来源 :2014北京协和急诊医学国际高峰论坛 | 被引量 : 0次 | 上传用户:sun_sun
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  急性肺损伤(acute lung injury,ALI)/急性呼吸窘迫综合症(acute respiratory distress syndrome,ARDS)是指心源性以外的各种肺内外因素导致的急性、进行性、缺氧性呼吸衰竭,以弥漫性肺泡-毛细血管膜损伤导致的肺水肿和炎症为病理特征,ARDS是ALI的严重阶段,临床上致死率高。发病机制主要包括炎症反应、细胞凋亡、氧化应激等,近几年的研究发现促红细胞生成素(Erythropoietin,EPO)是一种具有多功能的内源性调节因子,对包括肺在内的各种组织损伤有一定的细胞保护作用,有可能成为临床上治疗ALI/ARDS的新方法。
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