Objective Hypoxia has been shown to inhibit reactive oxygen species (ROS) production in nucleus pulposus (NP) cells.The TP53-induced glycolysis and apoptosis regulator (TIGAR) has been reported to sup
Background and object Inflammatory damage plays an important role in cerebral ischemic pathogenesis and represents a new target for treatment of stroke.Shikonin has gained attention for its prominent
Background The Notch signaling pathway is an evolutionarily conserved intercellular signaling system that plays a central role during vascular development and in the physiology of vertebrates[1].The N
Background and object Apelin has been proved to protect the heart against ischemia/reperfusion (I/R) injury via the activation of phosphatidylinositol 3-kinase (PI3K)/Akt and extracellular signal-regu
Background After ischemia/reperfusion(I/R) injury of brain, there will be a lot of complex changes of pathophysiology in ischemic core and penumbra, many neurons from ischemia become apoptotic even ne
Objective Global cerebral ischemia commonly occurs in emergency situations such as stroke,cardiac arrest and surgery that leads to neuronal cell death, and eventually causes long-term neurological imp
Background and object Apoptosis is a major form of cell death in cerebral ischemia/reperfusion (I/R) pathogenesis and may represent a target for treatment.Diosmin (DM), a micronized purified flavonoid
Background and Objective Subarachnoid hemorrhage (SAH) results in significant long-lasting neurological sequelae.Therefore, evaluating acute and long-term outcomes after therapeutic intervention is cr
Objective Little is known about the clinical practice of deep vein thrombosis (DVT) prophylaxis in patients with acute ischemic stroke in China.We examined the adherence rate and determinants of DVT p
目的 高尿酸可以导致未来卒中发生及死亡风险增加,同时也与糖代谢异常关系密切.但是对于尿酸与卒中结局的关系的研究结论一直不确定,高尿酸对合并不同糖代谢异常的卒中结局的不同影响的研究很少,结论也不清楚.方法 选自ACROSS-China数据库,有尿酸值共3306名急性首发卒中患者.依据口服葡萄糖试验及既往史,将所有人群分为糖尿病组,糖尿病前期组及正常糖代谢组,本研究分析选取正常糖代谢患者.住院期间不良