【摘 要】
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Abstract : Endosulfan is a persistent organic pollutant and widely used in agriculture as a pesticide.To investigate the effect of endosulfan on meiosis pro
【机 构】
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Department of Toxicology and Hygienic Chemistry, School of Public Health,Capital Medical University,
【出 处】
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第六届亚洲特大城市环境与公共健康论坛暨中国环境科学学会环境医学与健康分会2015年会
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Abstract : Endosulfan is a persistent organic pollutant and widely used in agriculture as a pesticide.To investigate the effect of endosulfan on meiosis process, 32 rats were divided into 4 groups, treated with 0, 1, 5 and 10 mg/kg/day endosulfan respectively,and sacrificed after the 21 treatments.Results showed that endosulfan caused the reductions in concentration and motility rate, resulted in an increase in abnormality rate of sperm;further, endosulfan induced down-regulation of Sohlh1 which controls the switch on meiosis in mammals, as well Cyclin A1, CDK1 and CDK2.In vitro,endosulfan induced G2/M phase arrest of spermatogenic cell cycle and proliferation inhibition.The results suggested that endosulfan could inhibit the start of meiosis by down-regulating the expression of Sohlh, and induce G2/M phase arrest of cell cycle by decreasing the expression of Cyclin A1, CDK1 and CDK2 via oxidative damage,which inhibits the meiosis process, and therefore decrease the amount of sperm.
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