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Objective To compare the predictive value of the SYNTAX score according to different stratification in patients undergoing percutaneous coronary intervention for complicated coronary artery disease.Methods From Jan.2007 to Dec.2008, SYNTAX score were retrospectively calculated in 190 patients with three-vessel or left-main coronary artery disease.Follow up was carried out by telephone or outpatient interview.The end point were major adverse cardiac or cerebrovascular events (MACCE), a composite of death, nonfatal myocardial infarction (MI), stroke, and repeat revascularization.MACCE rates according to different stratification of SYNTAX score were recorded respectively.Cox proportional hazards model was used to calculate hazard ratiosand corresponding 95% CIs and control the confounding factors.Area under receiving operator curve(AUROC) were calculated to compare the predictive value of the two different stratifications.Results (1) MACCE rates of low (0-20.5) , intermediate (21.0-31.0), and high (≥31.5) tertiles according to SYNTAX score of our study population were 9.1%, 16.2% and 30.9% respectively (Log rank P=0.006,multivariable analyses HR 2.07, 95% CI 1.25 to 3.44, P=0.005).AUROC was 0.667 (95%CI 0.564-0.770, P=0.004).(2) MACCE rates of low (0-22) , intermediate (23-32), and high (≥33) tertiles according to SYNTAX score of SYNTAX study were 15.7%、 12.9% and 28.6% respectively (Log rank P=0.09, multivariable analyses HR 1.47, 95% CI 0.94 to 2.32, P=0.10).AUROC was 0.593 (95%CI 0.475-0.710,P=0.11).Conclusions SYNTAX score tertiles according to overall SYNTAX score distribution of our study population (0~20.5, 21.0~31.0, ≥31.5) could be an independent predictor of MACCE.However, SYNTAX score tertiles according to SYNTAX study (0~22, 23~32, ≥33) failed to predict MACCE occurrence of our study population.