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Regulatory genes play an important role in antibiotic biosynthesis and morphological differentiation in Streptomyces.sanG encoding a transcriptional activator is important for nikkomycin biosynthesis and sporulation in Streptomyces ansochromogenes [1].Disruption of sanG abolished nikkomycin biosynthesis,reduced sporulation and led to brown pigment accumulation.All aspects of this complex phenotype could be complemented by a single copy sanG which was integrated into the chromosome.