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Ginseng, the root of Panax ginseng C.A.Meyer (Araliaceae), has been extensively used in traditional oriental medicine for the prevention and treatment of aging-related disorders for over 2000 years.Accumulating evidence suggests that ginsenosides such as Rgl and Rbl, which are the pharmacologically active ingredients of ginseng, modulate neurotransmission.Synapsins are abundant phosphoproteins essential for regulating neurotransmitter release.