【摘 要】
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Nonalcoholic fatty liver disease (NAFLD) marked with steatosis is usually associated with metabolic diseases including obesity and type 2 diabetes mellitus
【机 构】
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DepartmentofCellBiologyCollegeofLifeSciencesWuhanUniversityChina
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Nonalcoholic fatty liver disease (NAFLD) marked with steatosis is usually associated with metabolic diseases including obesity and type 2 diabetes mellitus (T2DM), and has become one of the major health issues of modem human being.In the present study, the effect of high fat induced maternal obesity on NAFLD development and whether this impact can be transgenerational transmitted were investigated.We fed C57BL/6 mice with high fat diets or normal diets for three generations, high fat-fed males (HF P), high fat-fed male offspring from obese mothers (HF F1), high fat-fed male offspring (HF F2) of high fat-fed obese female F1, and their sex and age matched and generation matched controls (C P, C F1 and C F2) were collected.
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