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The aim of the present study was to identify ERCC1 genotypes in lung adenocareinoma patients.We observed that ERCC1 rs2589, C/T genotype (p =0.05; OR =1.72, 95% CI: 1-3.11), rs25487,C/C genotype (p =0.00002); OR =3.22, 95% CI: 1.79-5.89) and rs11615, A/A genotype (p =0.003; OR =5.89 CI: 1.56-26.11) were associated with lung cancer risk in our population.The analysis of cancer patients according to risk factor showed that wood smoke exposed patients (W) had an association of rs2589 C/T genotype that was not identified in tobacco smokers (T) and patients in whom no association with a known risk factor could be establish (N).On the contrary groups T and N had a significantly overall risk of cancer associated with rs11615 A/A genotype but not W patients.The 3 groups had an association with rs25487 C/C genotype particularly W subjects.