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Reduction of antibiotics，Using zine oxide instead of antibiotics，High level of zinc oxida (ZnO) be an effective strategy to prvent post weaning diarrhoea.How we can manage post weening dlarrhoea (E.coli)without using high level of zinc oxide?Reduce buffering capacity of feed，A mount of HCL required to reduce 1 kg of feed (PH4)，Proteins,minerala(e.g. SBM,DCP,limestone……).