【摘 要】
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The application of photodynamic therapy (PDT) in the treatment of cancer has remarkable advantages over conventional chemotherapy,due to its quick therapeut
【机 构】
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Division of Chemistry and Biological Chemistry,Nanyang Technological University,21 Nanyang Link,6373
【出 处】
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The Third Symposium on Innovative Polymers for Controlled De
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The application of photodynamic therapy (PDT) in the treatment of cancer has remarkable advantages over conventional chemotherapy,due to its quick therapeutic effect [1,2].However,poor water solubility of photosensitizers often limitstheir pharmacokinetic properties,hence reducing thetherapeutic efficacy in biological systems.In this work,polyacrylic acid (PAA) based nanoparticles (NPs) were synthesized through the supramolecular self-assembly (Fig.1) and employed as a vehicle for the delivery of a type Ⅱ photosensitizer,silicon phthalocyanine (SiPc),into cancer cells for the PDT application.
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