【摘 要】
：
Population studies show a relation of alcohol drinking to an increased risk of breast cancer (BrCa).Aiming to investigate uncertainties about a risk threshold, the role of beverage type and interactio
【机 构】
：
Kaiser Permanente Medical Center USA
【出 处】
：
BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
Population studies show a relation of alcohol drinking to an increased risk of breast cancer (BrCa).Aiming to investigate uncertainties about a risk threshold, the role of beverage type and interactions with other BrCa predictors, we performed a cohort study among 70,033 women, 2,829 of whom developed BrCa.Using Cox proportional hazards models with 8 covariates, the following relative risks (95% confidence intervals) for BrCa versus lifelong abstainers were found: 1.08 (0.95-1.22) at <1 drink per day, 1.21 (1.05-1.40, p=0.01) at 1-2 drinks daily and 1.38 (1.13-1.68, p=0.002) at > or =3 drinks daily.Increased BrCa risk was concentrated in women with oestrogen receptor positive tumours with no major disparity related to choice of wine, liquor, beer or type of wine (red, white, etc).We conclude that with a threshold below 1-2 drinks daily, a hormone-related mechanism mediates a relation of alcohol drinking to an increased BrCa risk.
其他文献
目的：观察抗纤益心方对扩张型心肌病大鼠心肌基质金属蛋白酶-3(MMP-3)及其抑制剂-3(TIMP-3)表达的影响。方法：喂饲呋喃唑酮8周建立扩张型心肌病动物模型，随机分组后药物干预8周，检测心肌MMP-3及TIMP-3的表达。结果：与模型组比较：中西药联用组、中药大剂量组、中药小剂量组和卡托普利组均能明显下调MMP-3表达(P均<0.05)，上调TIMP-3蛋白表达(P均<0.05)。结论：抗纤
动脉粥样硬化急性事件最主要的深层原因，是易损斑块及在此基础上斑块破裂和／或合并血栓形成。认识易损斑块的内在特性和破裂机制，对于早期检测和处理易损斑块、预防和治疗血管急性事件(动脉硬化血栓形成、血栓栓塞、闭塞)具有重要的意义。本文介绍了易损斑块与血栓、炎症机制与斑块易损性等内容，并就预示斑块易损的血清学标志物进行了分析，简述了解毒方药稳定易损斑块的研究进展。
目的：探讨化痰活血法治疗心脏神经官能症的疗效。方法：将患者随机按2：1分为两组，治疗组80例给予化痰活血方药，对照组给予倍他乐克、舒乐安定片等西药，共治疗30天。结果：治疗组治愈65例，好转11例，总有效率95.00％;对照组治愈20例，好转8例，总有效率70.00％。治疗组疗效明显优于对照组(P<0.01)。结论：化痰活血法治疗心脏神经官能症疗效显著。
目的：观察血塞通软胶囊对大鼠缺血心肌血管新生和缺血心肌血管内皮生长因子mRNA(VEGFmRNA)表达的影响。方法：结扎大鼠左冠状动脉后，随机分为血塞通软胶囊组、麝香保心丸组(阳性对照)、模型组(阴性对照)，并设假手术组。6周后检测各组大鼠缺血心肌中微血管数(MVC)、微血管密度(MVD)及VEGFmRNA的表达及其灰度值。结果：模型组、麝香保心丸组及血塞通软胶囊组大鼠心肌梗死边缘区MVC和MVD
动脉硬化闭塞症(arteriosclerosis obliterans，ASO)是全身性动脉粥样硬化在肢体局部的表现，近年来，越来越多的证据表明血管内皮细胞是一个内分泌、旁分泌和自主分泌的器官。在调节血管张力和维持血管内环境稳定中起着重要作用。血管内皮功能障碍是动脉粥样硬化病理过程中的早期改变，是发生动脉硬化的最初事件，即“启动子”，且对动脉硬化的进展有重要影响，而炎症反应可能是AS和血管内皮功能
目的：研究益气、活血软坚、解毒(YHRJ)不同治法对荷S180瘤小鼠肿瘤生长抑制效应。方法：荷S180腹水瘤小鼠造模后随机分成对照组、益气、活血软坚、解毒组，第2天开始用药，于第13天拉颈处死动物，取出瘤组织，称重。结果：各折方用药组均有明显抑制肿瘤生长作用，与NS组比较，差异显著，(P<0.05)以活血软坚组抑瘤率最高，为51.71％，差异显著。结论：益气、活血软坚、解毒法对小鼠S180腹水瘤生
Breast cancer incidence increases with age and due to the current trend to delay pregnancy later in life, the rare coincidence of breast cancer and pregnancy has become more frequent.Gestational breas
The mammalian target of rapamycin (mTOR) controls cell proliferation and survival and has a central role in the regulation of cancer cell growth.This pathway is activated in many human cancers.Rapamyc
Antiprogestins were synthesized in the mid 1980s and the bulk of investigations on these compounds were geared toward their contraceptive properties.The prototypical member of this family, mifepriston
Breast cancer death is caused by invasive and metastatic cancer that is preceded by a pre-invasive stage, ductal carcinoma in-situ (DCIS).DCIS represents the ideal target in a strategy to prevent prog