Synthesis of γ-Lactam Derivatives via Intramolecular Ene Reaction

来源 :The 24th International Society of Heterocyclic Chemistry Con | 被引量 : 0次 | 上传用户：ILOVELUBIN

【摘要】

：

【作者】

：

Jinlong Wu Jian Zhang Wei-Min Dai

【机构】

：

Laboratory of Asymmetric Catalysis and Synthesis,Department of Chemistry,Zhejiang University,Hangzho

【出处】

：

The 24th International Society of Heterocyclic Chemistry Con

【发表日期】

：

2013年4期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Intramolecular ene reactions of the chiral amides 1 and 3 have been established by heating at 160 ℃ in MeCN in sealed vial to furnish the highly functionalized γ-lactams 2 and 4 with good regio-and stereoselectivity.These γ-lactams might be usefully for synthesis of kainic acid analogues.

其他文献

Chiral Gold Complex-Catalyzed Hetero-Diels-Alder Reaction of Diazenes: Highly Enantioselective and G

A chiral gold(Ⅰ) complex-catalyzed highly regio-and enantioselective azo hetero-Diels-Alder reaction has been developed.The chiral gold(Ⅰ) complex acting as a Lewis acid exhibits high efficiency in th

会议

Synthesis of 2-epi-Fagomine Using Gold(Ⅰ)-catalyzed Allene Cyclization

A synthesis of 2-epi-fagomine via a highly stereoselective gold(Ⅰ)-catalyzed allene cyclization is described.The stereochemical outcome of the cyclisation is opposite to that observed in previous stud

会议

Enantioselective Organocatalytic Addition of Nitroalkanes to Oxindolylideneindolenines for the Const

An enantioselective organocatalytic addition of nitroalkanes to oxindolylideneindolenines in the presence of bifunctional organocatalysts has been established to provide an efficient entry to 3,3-disu

会议

Total Synthesis of Tubingensin A

The first total synthesis of tubingensin A was finished starting from an advanced intermediate of anominine.The synthesis features a CuOTf-promoted 6π-electrocyclization/aromatization sequence to forg

会议

Gram Scale Synthesis of Key Intermediate of Taiwaniaquinoids

A gram scale approach was developed toward the advanced intermediate of taiwaniaquinoids.This intermediate 5a with trans A/B ring junction was concisely assembled by employing a Bi(OTf)3-catalyzed cat

会议

Construction of Spiro-tetrahydroquinolines via Intramolecular Dearomatization of Quinolines: Free of

The stereoselective synthesis of spiro-tetrahydroquinolines has been realized via cacade hydrogenative dearomatization[1] of quinoline and aza-Friedel-Crafts reaction.This methodology features ready a

会议

Highly Regioselective Allylic Substitution Reactions Catalyzed by an Air-stable (π-Allyl)iridium Com

We report an air-stable (π-allyl)iridium complex derived from dinaphthocyclooctatetraene and a phosphoramidite ligand.It was found highly efficient in iridium-catalyzed allylic substitution reactions.

会议

Asymmetric Synthesis of Tetrahydro-β-carbolines via Chiral Phosphoric Acid Catalyzed Transfer Hydrog

An efficient synthesis of enantioenriched tetrahydro-β-carbolines via chiral phosphoric acid catalyzed enantioselective transfer hydrogenation of hydroxylactams has been achieved.This methodology feat

会议

A Chiral Ruthenium-Monophosphine Catalyst for Asymmetric Addition of Arylboronic Acids to Aryl Aldeh

Chiral diarylmethanols are important building blocks for many antihistamine compounds or therapeutic agents such as (R)-orphenadrine, (S)-neobenodine, (S)-carbinoxamine, and bepotastine.catalytic meth

会议

Design of Phosphorus Ligands with Deep Chiral Pockets: Practical Synthesis of Chiral β-Arylamines by

Chiral β-arylamines exist in numerous biologically interesting natural products and therapeutic agents.They also serve as pivotal structural units for many active pharmaceutical ingredients.We have su

会议

Synthesis of γ-Lactam Derivatives via Intramolecular Ene Reaction

其他学术论文