In vivo visualization of pancreatic □-cell function in zebrafish using dual-color two-photon three-a

来源 :The 9th Asian Biophysics Association Symposium (ABA2015)(第九届 | 被引量 : 0次 | 上传用户：liandakj2005

【摘要】

：

Pancreatic beta-cell plays a central role in the body blood homeostasis by systematically activating glucose uptake after food intake.Diabetes arises when beta-

【作者】

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Jia Zhao Weijian Zong Fuzheng Niu Xuan Zheng Aiming Wang Yanmei Liu Liangyi Chen

【机构】

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TheStateKeyLaboratoryofBiomembraneandMembraneBiotechnology,InstituteofMolecularMedicine,PekingUniver

【出处】

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The 9th Asian Biophysics Association Symposium (ABA2015)(第九届

【发表日期】

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2015年5期

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Pancreatic beta-cell plays a central role in the body blood homeostasis by systematically activating glucose uptake after food intake.Diabetes arises when beta-cells are unable to meet insulin demand in the body, either due to a decrease in beta-cell mass or deterioration of beta-cell function [1].A potential strategy is to generate massive functional beta-cells in vitro from stem cells before transplantation into patients to correct the glucose intolerance.Despite recent progresses, generation of fully functional pancreatic beta-cells in vitro is still not accomplished, which is due to the little understanding of functional maturation of pancreatic beta-cells during development in vivo.

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In vivo visualization of pancreatic □-cell function in zebrafish using dual-color two-photon three-a

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