Association between exposure to organophosphate pesticide and thyroid hormones in pregnant women

• 作 者: Yiwen Wang Limei Chen Caifeng Wang Yi Hu Yu Gao Yijun Zhou Rong Shi Yan Zhang Michihiro Kamijima Jun Ueyama Ying Tian
• 机 构: MOEandShanghaiKeyLaboratoryofChildren'sEnvironmentalHealth,XinhuaHospital,ShanghaiJiaoTongUniversit
• 出 处: 第六届亚洲特大城市环境与公共健康论坛暨中国环境科学学会环境医学与健康分会2015年会
• 发表日期: 2015年10期
• 关键词: organophosphate pesticide thyroid hormone pregnant women

　　Although animal studies suggested that organophosphate pesticides (OPs) can affect the thyroid function, little is explored in human populations.We investigated the association between OPs and thyroid hormones in Shandong, by enrolling 637 pregnant women from April 2011 to December 2013.OP exposures were assessed by analyses of dialkylphosphate (DAP) metabolites (n=413) and the concentration of thyroid hormones were measured (n=325) in pregnant women.We analyzed the relationship between DAP metabolites and thyroid hormones (n=325).Median levels of DAP metabolites were 9.81μg/L for dimethylphosphate (DMP), 0.79μg/L for dimethylthiophosphate (DMTP), 5.00μg/L for diethylphosphate (DEP), and 0.78μg/L for diethylthiophosphate (DETP).We found that total DAP concentration was negatively associated with thyroid stimulating hormone levels (β =-0.15, 95% confidence interval (CI):-0.24 to-0.05) and postively associated with free T4 levels (β =0.14, 95% CI: 0.01 to 0.26).The findings suggest that OP exposures may disrupt thyroid function in pregnant women.