Association between HLA allele and carbamazepine induced maculopapular exanthema reactions in the so

• 作 者: Fu-Li Min Ze Li Xiao-Ping Pan Wei-Ping Liao Yi-Wu Shi
• 机 构: department of neurology,Guangzhou First people's hospital,Pan-Fu Road,Guangzhou 510000,China
• 出 处: 广东省医师协会第五届神经内科医师大会
• 发表日期: 2015年6期

Purpose Previous study indicated that HLA-B*1502 is strongly associated with carbamazepine(CBZ)induced Stevens-Johnson syndrome(SJS)and toxic epidermal necrolysis(TEN)in Han Chinese,while HLA-A*3101 is associated with CBZ induced cutaneous adverse reactions in Japanese and European.However,the relationship between HLA allele and CBZ induced maculopapular exanthema reactions(CBZ-MPE)was unclear.We thus investigated the involvement of HLA-A,B,C,DRB1 alleles in CBZ-MPE in southern Han Chinese patients.Method We carried out a case-control association study.We enrolled 60 CBZ-MPE,137 CBZ tolerant subjects and 5270 healthy volunteers as normal controls.The ethnicity of all cases and controls was Han Chinese.,coming from locations in southern China.Sequencing for four-digit genotyping was performed.A 2-by-2 x2 test or Fishers exact test was used.Results HLA-B*1502 was present in 11 of 58(18.9％)CBZ-MPE,HLA-A*3101 was present in 5 of 60(8.3％)CBZ-MPE,the frequency of HLA-B* 1502,HLA-A*3101 in CBZ-MPE did not differ significantly from that in CBZ-tolerant controls and normal controls.Conclusion No significant association between HLA allele and CBZ-MPE was found.The associations between CBZ-MPE and HLA alleles warrant further studies.