Folic Acid Enhanced Gene Delivery of Cationic Lioposome

来源 :2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学术年会、中国化学制药工业协会固体制剂专业委员会2016年 | 被引量 : 0次 | 上传用户:kongxf04
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  In our study,we used cholesterol(Chol)as helper lipid and folic acid(FA)as targeting ligand to enhance gene delivery of a novel N-[1-(2,3-didodecylcarbamoyloxy)propyl]-N,N,N-trimethylammonium iodide(DDCTMA)cationic liposome.
其他文献
Solid lipid nanoparticles(SLNs)have been proposed as suitable colloidal carriers for delivery of drugs with limited solubility.In this work,KP-loaded SLNs were prepared,and the characteristics of the
会议
Immunotherapy has shown great promise in treating a variety of cancers,leading to durable responses and lifelong survival.Nanomedicine plays a vital role in improving drug delivery to tumors and tumor
会议
Presently,the majority of effective chemotherapy agents are administrated by in jection,resulting in reduced patient compliance.Oral delivery is considered to be a preferred route for drug administrat
会议
Tumor metastasis is the main reason making tumor lethal.Despite the spontaneous metastasis,treatment against tumor,such as surgical therapy,radiotherapy,chemotherapy and even target therapy,may induce
Multiple treatment strategies were frequently applied in anti-tumor therapy in clinic.However,numerous tumors developed resistance to the drugs originally used to treat them and even worse became cros
会议
Most of chemical drugs or gene drugs couldnt find their target sites in tumor cells by themselves,which leads to low efficiency,severe systemic toxicity,drug resistance and tumor metastasis.
To improve clinical treatment and reduce the side effects in endometriosis-associated pain chemotherapy,lipid grafted chitosan polymer(CSO-SA)coated nanostructured lipid carriers(NLC)have been develop
A non-negligibly representative non-tumor cells-tumor associated fibroblast cells(CAFs)has a very important effect on tumor proliferation,invasion and metastasis processes.