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  5. Pharmacokinetic Interaction Study of Fentanyl with Fluoxetine Using HPLC-UV after Intraperitoneal Ad

Pharmacokinetic Interaction Study of Fentanyl with Fluoxetine Using HPLC-UV after Intraperitoneal Ad

来源 :第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会 | 被引量 : 0次 | 上传用户：Tengshuo
【摘 要】
：
Fentanyl is an opioid analgesic, which is commonly used to treat break through pain in cancer patients or as a pre-procedure anesthetic agent.Recently, mortality cases were reported due to co-administ
【作 者】
：
Mitsuhiro Wada Ahmed A.Almousa Rie Ikeda Ruri-kikura Hanajiri Naotaka Kuroda Kenichiro Nakashima 
【机 构】
：
Graduate School of Biomedical Sciences, Course of Pharmaceutical Sciences, Nagasaki University, Naga
【出 处】
：
第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
【发表日期】
：
2011年3期
【关键词】
：
Fentanyl Fluoxetine Rat plasma HPLC-UV Pharmacokinetics 
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　　Fentanyl is an opioid analgesic, which is commonly used to treat break through pain in cancer patients or as a pre-procedure anesthetic agent.Recently, mortality cases were reported due to co-administration of fentanyl and other SSRIs like fluoxetine, which is proposed to have metabolic interaction by a liver enzyme CYP3A.A new HPLC-UV method coupled with simple liquid-liquid extraction was developed for fentanyl determination in rat plasma and utilized to elucidate pharmacokinetic behavior of fentanyl after a pre-administration of fluoxetine.
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