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Single cell-ICP-MS or single particle-ICP-MS is an emerging technique for the analysis of nanoparticles or cells.[1,2] It is well known that conventional ICP-MS with a quadrupole mass analyzer has limitation in such analysis,due to the one mass measurement at a time.This contrasts with the simultaneous multi-elemental analysis performed by ICP-TOF-MS,in which a broad range of isotopes can be measured.