Supplementary of unsaturated fatty acids during perinatal periods obviously relieve the brain injury

• 作 者: Wen-TingZHANG;HuiGAO;Yan-QinGAO;
• 机 构: State key laboratory of Medical Neurobiology, Shanghai Medicine College, Fudan University, Shanghai
• 出 处: 中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
• 发表日期: 2007年期

　　Objective Perinatal hypoxia-ischemia is an important cause of brain injury in newborns,with a high risk of future behavioral and neurological deficits.It is also the major cause of neurological diseases such as dementia,epilepsy and paralysis.Neuronal apoptosis play an important role in perinatal hypoxia-ischemia.Nowadays,people use olive oil for cooking and/or get extra fish oil daily for health,in order to prevent against the stroke and cardiovascular diseases.Both fish oil and olive oil are found in significant amount of unsaturated fatty acids (UFA),which including Monounsaturated fatty acid (mainly α-linoleic acid) and polyunsaturated fatty acids (for example α-linolenic acid,Eicosapentaenic acid and Docosahexaenic acid).They are essential components of the biomembrane and play an important role in the most of physiological process in brain like excitable membrane function,memory and neuroprotection.In the present study,our purpose is to determine whether supplementation of fish oil and olive oil could protect neurons from apoptosis in hypoxiaischemia injury.