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  5. Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channel via GHS-R1a

Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channel via GHS-R1a

来源 :International Conference for Physiological Sciences 2012(201 | 被引量 : 0次 | 上传用户：stupid199001
【摘 要】
：
Ghrelin enhances neuronal firing in substantia nigra pars compacta (SNc) where excitability of dopaminergic neurons determines the function of nigrostriatal system for motor coordination.However, how
【作 者】
：
Limin Shi Xiling Bian Zhiqiang Qu Zegang Ma Yu Zhou Kewei Wang Hong Jiang Junxia Xie 
【机 构】
：
Department of Physiology,,Medical College of Qingdao University,Qingdao,China
【出 处】
：
International Conference for Physiological Sciences 2012(201
【发表日期】
：
2012年8期
【关键词】
：
ghrelin excitability KCNQ 
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　　Ghrelin enhances neuronal firing in substantia nigra pars compacta (SNc) where excitability of dopaminergic neurons determines the function of nigrostriatal system for motor coordination.However, how ghrelin regulates the neuronal excitability remains unknown.Here we describe a novel mechanism by which ghrelin enhances neuronal firing by inhibiting Kv7/KCNQ/M-channel through its receptor GHS-Rla-activated PLC-PKC pathway.
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