Targeted Opening of the Blood Brain Barrier by Photodynamic Therapy

• 作 者: HenryHirschberg;QianPeng;FranciscoA.Uzal;DavidChighvinadze;MichelleJ.Zhang;SteenJ.Madsen;
• 机 构: Beckman Laser Institute University of California USA
• 出 处: BIT Life Sciences' 1st Annual World Cancer Congess-2008(
• 发表日期: 2008年期

　　Eradication of infiltrating glioma cells poses a significant clinical challenge that is unlikely to be solved using conventional treatment regimens.This is due to the fact that these migratory cells are protected by the blood brain barrier (BBB) which prevents the delivery of chemotherapeutic agents or photosensitizers.We have evaluated the ability of Photodynamic therapy (PDT) to selectively open the BBB.This will permit access of chemotherapeutic agents to brain tumor cells, but limit their penetration into normal brain remote from the site of illumination.PDT was performed on non tumor bearing inbred.Fisher rats at increasing fluence levels.Post-contrast T1 MRI scans were used to monitor the degree BBB disruption which can be inferred from the intensity and size of the contrast agent visualized.F98 tumor cells were also implanted into the brains of some animals following PDT and ehemo-therapeutie agents were thereafter administered.