Global Polarization Effect of Zn2+ on the Region 1-16 of Amyloid-Beta Peptide

• 作 者: Yan-DongHuang;Jian-WeiShuai;
• 机 构: Department of Physics and Institute of Theoretical Physics and Astrophysics, Xiamen University, Xiam
• 出 处: 中国物理学会2012年秋季学术会议
• 发表日期: 2012年期

Zinc is critical in Alzheimers disease (AD) pathogenesis and one direct evidence is that Zinc is found saturated in the deposited Amyloid-beta (AB) peptide plaques in AD patients brains.Zinc binding to AB promotes the amyloid aggregations,including the toxic soluble AB species.