【摘 要】
：
The liver is the largest organ in our body,and our lives will be threatened if our livers do not work.The artificial liver support system may bridge patients to liver transplantation due to the system
【机 构】
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1Center for Biomedical Engineering,University of Science and Technology of China,Hefei,Anhui 230027,
【出 处】
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2014年上海市研究生学术论坛:生物医疗仪器
论文部分内容阅读
The liver is the largest organ in our body,and our lives will be threatened if our livers do not work.The artificial liver support system may bridge patients to liver transplantation due to the system may help patients live longer for transplantation.Although artificial liver supporting systems have been improved in modern medical engineering,the assistant therapeutic effect of the artificial liver is still need to be improved.Here,we present a miniature liver on a chip for assist therapy of liver failure.The device is designed in the form of a sandwich which composed by three polymethyl methacrylateplates that contain microchannels and two layers of chitosan macroporous membranes.The structure and function of the device mimic the liver lobule tissue after liver cells cultured in the system.In addition,the design is flexible and it can be used in many fields such as the assist support therapy system for liver failure patients,the in vitro model for liver toxicity testing and the platform for cell co-culture.In order to prove the effectiveness of the design,several experiments were performed.The results showed that hepatocytes were cultured well in the device and the concentration of hepatoxin in medium was decreased.Therefore,the presented bio-artificial liver on a chip is functional and versatile platform,and capable of providing support for the development of artificial liver and the therapy of liver disease.
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