【摘 要】
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Neuroblast development involves asymmetric cell division, migration, apoptosis and neuritogenesis.We study the molecular and cellular mechanisms underlying
【机 构】
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TsinghuaUniversity,Beijing,China
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Neuroblast development involves asymmetric cell division, migration, apoptosis and neuritogenesis.We study the molecular and cellular mechanisms underlying Q neuroblast development in C.elegans.We have developed fluorescence live cell imaging methodologies to document Q cell development;and we have also devised somatic CRISPR-Cas9 technique to generate conditional mutations within Q cell lineages.In a combination with imaging, genetic and biochemical approaches, we discovered a new type of asymmetric cell division and the regulatory mechanisms;we illustrated the fate of midbody after asymmetric cell division;and we demonstrated the roles ofactin-binding protein Coronin and Anillin in organizing the actin cytoskeleton during neuroblast migration.Recently, we have identified an evolutionarily conserved membrane protein MIG-13 as a key regulator that functions autonomously during Q cell migration.We further uncover two parallel pathways that respectively transduce the MIG-13 signal to the WASP and WAVE complexes to promote the nucleation of the aetin cytoskeleton in the leading edge.I here discuss our recent progresses in Q cell directional migration.Given that these components have homologs in vertebrates, our results can provide insights to mammalian neural development.
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