【摘 要】
：
Rheumatoid arthritis (RA) is a chronic inflammatory disease that mainly attacks the joints,causing synovitis.Around 1% of the worlds population suffers from RA and the disease is more common in women
【机 构】
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Membrane Assay Development Solvo Biotechnology Hungary
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
Rheumatoid arthritis (RA) is a chronic inflammatory disease that mainly attacks the joints,causing synovitis.Around 1% of the worlds population suffers from RA and the disease is more common in women than in men.For the treatment of RA three drug groups are used:non-steroidal anti-inflammatory drugs (NSAIDs) and steroids; biological agents and disease-modifying anti-rheumatic drugs (DMARDs).The last group is the most important as these agents not only relieve symptoms but also delay or halt the progression of the disease.These drugs should be administered for a longer period of time to be effective; at the same time it was discovered that resistance may be developed towards DMARDs.Some patients (5-10%) even show resistance from the beginning of the treatment.The cause for the resistance is multifactorial,one part of it being active extrusion of drug molecules from the cells by ABC transporters,most importantly ABCG2 (MXR/BCRP),shown to be expressed in disease affected synovial tissue but not in control samples.
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