Pharmacogenetics of medication-related osteonecrosis ofthe jaw:a systematic review and meta-analysis

• 作 者: Zhiyong Guo Weitong Cui Lin Que Xiufa Tang Jiyuan Liu Chunjie Li
• 机 构: West China Hospital of Stomatology
• 出 处: 2019中国肿瘤学大会
• 发表日期: 2019年7期
• 关键词: pharmacogenetics osteonecrosis of jaw bisphosphonates genetics systematic review

　　Objective Bisphosphonates are commonly administered as bone-specific anti-resorptive agents to patients who at increased risk of developing osteoporosis,multiple myeloma(MM),Pagets disease,and bone metastases.Medication-related osteonecrosis of the jaw(MRONJ)is a severe complication that can develop within patients treated with antiresorptive drugs.