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Two approaches of computational systems biology are presented:pathway reconstruction and kinetic modeling.In framework of these approaches we mine,collect and integrate quantitative in vitro and in vivo experimental data produced by classical biochemistry,genomics,proteomics and metabolomics and use them to build and verify kinetic models [1,2].These kinetic models when considered as a repository of all information about the system of interest can be applied to different problems of drug discovery [3] such as screening optimization [4] and investigation/prediction of drug safety [5].