论文部分内容阅读
Cancer biomarker plays an important role in cancer diagnosis and treatment,but very few robust cancer molecular biomarkers are discovered in the last decades.This requires us to explore the causes to fail to find robust biomarker genes.One of the reasons is that many researchers lack the necessary analysis of the clinical cancer samples to some degree and ignore the effect of sample size and unbalance on finding robust biomarker.Here we proposed three methods to study their effects on finding cancer biomarker genes in order to attract more and more scientists attentions.Experimental results show that the number,stability and robustness of biomarker genes have significant change when sample size and ratio change.