【摘 要】
：
环境暴露可以改变基因的表观遗传状态,如DNA甲基化的改变.基因的表观遗传学变化是链接环境因素与人体健康的一个重要纽带,可以反映人体受环境因素的影响,以及潜在的健康风险.
【机 构】
：
深圳市太空科技南方研究院;中国航天员科研训练中心深圳市太空科技南方研究院中国航天员科研训练中心中国科学院西双版纳热带植物园
【出 处】
：
第三届数学、计算机与生命科学交叉研究青年学者论坛
论文部分内容阅读
环境暴露可以改变基因的表观遗传状态,如DNA甲基化的改变.基因的表观遗传学变化是链接环境因素与人体健康的一个重要纽带,可以反映人体受环境因素的影响,以及潜在的健康风险.为了系统了解环境因素的表观遗传学效应,我们建立了"环境DNA甲基化数据库"(Database of DNA Methylation Marker for Environmental Factors, DnaMe, http://dname.prebiomarker.info/)数据库基于文献挖掘与人工注释,目前已收集2012年至今所发表的科学文献,重点收录与特定环境因素相关的人类血液DNA甲基化变化信息.目前已收录超过100篇文献、2000多个基因的甲基化与环境因素的关联性.该数据库免费向学术界用户开放.
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