Effect of vasoactive intestinal peptide on oxidative stress of ALI

来源 :International Conference for Physiological Sciences 2012(201 | 被引量 : 0次 | 上传用户：tandge

【摘要】

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【作者】

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Guo-Ying Sun Cha-Xiang Guan Yong Zhou Hui Xie Li Peng Yong-Ping Liu

【机构】

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Department of Physiology,Xiangya School of Medicine,Central South University,Changsha,China

【出处】

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International Conference for Physiological Sciences 2012(201

【发表日期】

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2012年8期

【关键词】

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vasoactive intestinal peptide oxidative stress acute lung injury

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　　Acute lung injury (ALI) is damage of acute lung function and morphologica induced by oxygen free radical and prostaglandins.Oxidative stress often leads to release of many kinds of cytokine, and it is related to the pathogenesis of ALI.Vasoactive intestinal peptide (VIP) is the important neuropeptide in lungs, we observe VIP whether regulate oxidative stress of ALI.Objective: To investigate effect of VIP on oxidative stress in ALI.Methods: To build the pGC-FU-VIP lentiviral, and detect the activity of LDH and SOD and the content of MDA.Results: (1) The green fluorescent intensity is positively correlated with lentiviral titers.(2) VIP enhanced the SOD activity, but weakened LDH activity and reduced MDA content.Conclusion: VIP can reduce oxidative stress of mice lungs in ALI, thus inhibiting the neutrophil respiratory burst and finally in favour of lung tissue damage repair.

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Effect of vasoactive intestinal peptide on oxidative stress of ALI

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