【摘 要】
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Objective This study was designed to clear the quantitatively relationship between HBeAg and HBV DNA, and verify whether quantitative measurement of HBeAg could be used as a marker of viral replicatio
【机 构】
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State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospit
【出 处】
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第六届中国医师协会感染科医师大会暨传染病诊治高峰论坛、第十四届中华预防医学会微生态学学术会议
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Objective This study was designed to clear the quantitatively relationship between HBeAg and HBV DNA, and verify whether quantitative measurement of HBeAg could be used as a marker of viral replication in asymptomatic HBsAg-positive carriers.Methods A cross-sectional, community-based survey was carried out in 12 communities of two counties.724 asymptomatic carriers with HBeAg-positive were divided into four groups by HBV DNA levels.Cases in groups Ⅰ (n =99), Ⅱ(n =79), Ⅲ (n =98) and Ⅳ (n =448) were reported HBV DNA levels of < 103 (PCR undetectable), 103 to 105 (PCR detectable), > 105 copies/ml(hybridization detectable) and > 107 copies/ml, respectively.Results The HBeAg levels have a good correlation with HBV DNA (r =0.765;P < 0.001) on a log scale.The mean log HBeAg (S/CO) of group Ⅰ, Ⅱ, Ⅲ, Ⅳ were 0.66 ±0.54,0.98 ±0.81,1.49 ±0.92,3.10 ± 0.89, respectively.The mean log HBeAg level of group Ⅳ was significantly higher than that of the other groups.the best cut-off value of HBeAg in differentiating group Ⅳ from the other groups was 750 S/CO with a sensitivity of 97.3% and a specificity of 98.2%.Conclusion Quantitative measurement of HBeAg titres may be an easy and economical reference for HBV replication in HBV carriers.
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